Guest Speaker: Giorgio Sirugo, MD, PhD
Senior Research Investigator, University of Pennsylvania School of Medicine, and Adjunct Professor, CWRU Department of Population and Quantitative Health Sciences
Abstract: HIV-exposed uninfected (HEU) infants on antiretroviral therapy (ART) have increased morbidity and neurodevelopmental delays compared to HIV-uninfected unexposed infants (HUU). While ART prevents HIV vertical transmission, it can modify DNA methylation, affecting development. We examined ART's epigenetic impact in Botswana newborns, and identified several key genes with altered methylation patterns that may provide mechanistic insights into the observed HEU’s developmental vulnerabilities.
If unable to attend in person in Biomedical Research Building room 105, you may join via Zoom at
Meeting ID: 958 2937 2435
Passcode: 087450