ÃÛÌÒAPP

My research is primarily focused on the molecular biology of colon cancer, functional influence of oncogenes and suppressor genes on transformation, metastasis, and response to therapies. 

Sanford Markowitz's Biography 

We build synthetic nucleic acid nanoparticles (such as DNA origami) to advance gene therapies and artificial light harvesting systems. Our group utilizes multi step Förster resonance energy transfer and live cell imaging to address challenges in gene delivery.

Divita Mathur's Biography

I perform large-scale mutational experiments characterizing the impacts of protein coding variants on cell function, including infectious diseases and immunity.

Kenneth Matreyek's Biography

Research projects in the Matsuoka Lab aim to decode genetic programs controlling vascularization, vascular cell diversity, and barrier integrity in the central nervous system. We employ advanced genetic, imaging, and omics approaches to dissect these developmental mechanisms using the zebrafish in vivo model combined with human-derived endothelial cell culture in vitro. Our goal is to discover novel molecular targets from our basic science research and translate this knowledge into developing therapeutics that can repair vascular and neural abnormalities in neurological diseases. 

Ryota Matsuoka's Biography 

My research includes cell death regulation, mechanism of epigenetic aging, the biological significance of DNA methylation age determining the timing of death, and the development of cell death inhibiting small compounds.

Shigemi Matsuyama's Biography

My focus is in vascular function in health and disease; inflammation and thrombosis, antiphospholipid antibodies, and miRNA. 

My research involves neurobiology of the auditory hair cell: mechanotransduction, synaptic transmission, and development. I also research Zebrafish models of deafness.

I investigate lipid signaling molecules that control intracellular functions in human inflammation. I also research enzymes that make and inactivate lipid signaling molecules, and their roles in human disease.

Our research centers on how changes in the extracellular matrix results in dysfunctional heart development and resulting congenital heart defects. We utilize preclinical mouse models of congenital heart disease, cell culture, genomics, biochemistry, and proteomics to understand the molecular mechanisms underlying these diseases towards the development of therapeutic approaches. Our current major research focus is on the novel concept of inhibiting a protease that remodels fibrillin microfibrils in the aorta to identify a therapeutic for Marfan syndrome.

Timothy J. Mead's Biography 

My research focuses on structural and functional studies to reveal the impact of mitochondrial dynamics on cell health and proliferation in human diseases, including cancer, neurodegeneration and cardiomyopathy. My areas include cryo-electron microscopy, biochemistry, computational biology, and cancer stem cell models.

Jason A. Mears's Biography