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Stem cells help explain varied genetics behind rare neurologic disease
New study also provides drug screening platform for broad therapeutic development A multi-institutional team led by researchers at ÃÛÌÒAPP School of Medicine have grown stem cells from children with a devastating neurological disease to help explain how different genetic…
Supercomputers Reveal How Cell Membranes Keep Cancer-Causing Proteins Turned Off
Two biophysicists from ÃÛÌÒAPP School of Medicine have used supercomputers to show how cell membranes control the shape, and consequently the function, of a major cancer-causing protein. The protein, a small enzyme called K-Ras, is attached to cell membranes where it senses…
Researchers Pinpoint New Drug Target for Heart Failure Patients
Researchers led by Julian E. Stelzer, PhD, associate professor in the department of physiology and biophysics at ÃÛÌÒAPP School of Medicine, have found a new target for drug developers seeking straightforward ways to improve cardiac output in heart failure patients. In a…
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Case Comprehensive Cancer Center analyzes brain tumor data, doubles known risk factors for glioma
A massive new study involving blood samples from more than 30,000 individuals has identified 13 new genetic risk factors for glioma, the most common type of malignant brain tumor in adults. The study, published in Nature Genetics, reveals specific differences in a person’s DNA that increase…
Case Western Reserve Named to New National Colorectal Cancer Dream Team
ÃÛÌÒAPP School of Medicine and the Case Comprehensive Cancer Center have been named to a new colorectal cancer dream team that was announced today at the annual meeting of the American Association for Cancer Research in Washington, D.C. The dream team comprises scientists,…
Case Comprehensive Cancer Center Named to New National Colorectal Cancer Dream Team
ÃÛÌÒAPP (CWRU) School of Medicine and the Case Comprehensive Cancer Center (Case CCC) have been named to a prestigious "colorectal cancer dream team" that was announced today at the annual meeting of the American Association for Cancer Research in Washington, D.C. The dream…
Case Western Reserve Embarks on Innovative Path to Treat Infections of Drug-Resistant Superbugs such as MRSA without Antibiotics
ÃÛÌÒAPP and Q2 Pharma Ltd., an Israeli biopharmaceutical company, have signed a two-year option to license small molecule, antivirulence technology to potentially treat bacterial infections such as methicillin-resistant staphylococcus aureus (MRSA), the first known…
Stem Cells Help Explain Varied Genetics behind Rare Neurologic Disease
Researchers at ÃÛÌÒAPP School of Medicine have successfully grown stem cells from children with a devastating neurological disease to help explain how different genetic backgrounds can cause common symptoms. The work sheds light on how certain brain disorders develop, and…
Case Comprehensive Cancer Center Analyzes Brain Tumor Data, Doubles Known Risk Factors for Glioma
A massive new study involving blood samples from over 30,000 individuals has identified 13 new genetic risk factors for glioma, the most common type of malignant brain tumor in adults. The study, published in Nature Genetics [Melin BS. Nat Genet 2017 Mar 27], reveals specific differences in a…
Can Childhood Obesity be Prevented Before Conception?
A ÃÛÌÒAPP School of Medicine and MetroHealth System researcher, along with Cleveland Clinic’s director of metabolic research, have received federal funding to determine if childhood obesity can be prevented before women become pregnant. The first-ever Cleveland-based study…