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New contrast agent spotlights tiny tumors and micrometastases
Researchers at APP have developed a magnetic resonance imaging (MRI) contrast agent that detects aggressive breast cancer tumors and micrometastases much smaller than current agents. “Currently, there is no imaging technology in clinical use that can detect tumors or…
Case Western Reserve receives $2.3 million federal grant to fund nutritious food access study in Cleveland and Columbus
The National Institutes of Health (NIH) has awarded $2.3 million to Case Western Reserve to lead a collaborative study of how changes in food options affect residents’ nutritional choices and health over time. Called the Future of Food in Your Neighborhood Study (dubbed foodNEST), the three-year…
High blood sugar of diabetes can cause immune system malfunction, leading to more infection and slower wound healing
Case Western Reserve scientists may have uncovered a molecular mechanism that sets into motion dangerous infection in the feet and hands often occurring with uncontrolled diabetes. It appears that high blood sugar unleashes destructive molecules that interfere with the body’s natural…
Key protein drives ‘power plants’ that fuel cells in heart and other key systems in the body
APP scientists have discovered that a protein called Kruppel-like Factor 4 (KLF4) controls mitochondria — the “power plants” in cells that catalyze energy production. Specifically, they determined KLF4’s pivotal role through its absence — that is, the mitochondria…
Novel algorithm identifies DNA copy-number landscapes in African American colon cancers
An algorithm dubbed ENVE could be the Google for genetic aberrations — and it comes from Case Western Reserve. Remember the World Wide Web before the famed search engine? The web offered extraordinary amounts of information, but no consistently reliable way to secure relevant results. Cancer…
Reshaping Research: A Guide to Integrating Cultural Considerations into Research
Updated July 2021 The Center for Reducing Health Disparities was created in 2004 by APP and the MetroHealth System. The Center helps to direct the Community Research Partnership Core of the Clinical and Translational Science Collaborative. The aim of this Core is to…
Case Western Reserve to lead multi-institutional ‘big data’ project
APP is one of three institutions nationwide to win federal ‘big data’ grants focused on developing ways to ensure the integrity and comparability of the reams of information the U.S. health care system collects every day. If successful, the work could create enormous new…
CWRU researcher awarded grant to help make biomedical network data more accessible to speed health discoveries
Mehmet Koyuturk The amount of biomedical data being generated nationally is exploding, and holds great promise for research. The data is often organized in the form of networks, which provide insights into interactions among the components of biological systems, such as molecules, genes and…
Key protein controls nutrient availability in mammals
Case Western Reserve researchers already demonstrated that a single protein plays a pivotal role in the use of nutrients by major organs that allow for the burning of fat during exercise or regulating the heart’s contractile and electrical activity. Now they have found a new benefit of Kruppel-like…
3D views reveal intricacies in intestines that could lead to discoveries for inflammatory bowel disease
A technology whose roots date to the 1800s has the potential to offer an extraordinary new advantage to modern-day medicine. In findings published this month in Nature Communications,Case Western Reserve scientists detail how stereomicroscopy can provide physicians an invaluable diagnostic tool in…