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In Nature Opinion Piece, Case Western Reserve Researcher Calls for Animal-Human Embryo Research to Proceed – but with Strong Animal Protections
In a World View opinion column published in Nature, a APP School of Medicine researcher calls for animal-human embryo research to proceed – but only with strong animal protections in place. So-called “chimera” research raises the hope of producing human organs in…
APP School of Medicine Scientists Develop Therapeutic Protein, Protect Nerve Cells from Huntington’s Disease
A new scientific study reveals one way to stop proteins from triggering an energy failure inside nerve cells during Huntington’s disease. Huntington’s disease is an inherited genetic disorder caused by mutations in the gene that encodes huntingtin protein. Approximately 30,000 Americans have mutant…
Case Western Reserve Researcher Outlines Road Map for Addressing Ethical Concerns Tied to Research on Combination Human-Animal Embryos
Insoo Hyun, PhD, associate professor of bioethics at the School of Medicine of APP, has proposed a framework for addressing ethical questions surrounding potentially revolutionary research on part-human, part-animal embryos, which can be produced when human stem cells…
Case Western Reserve Researcher Awarded Drexel Prize in Translational Medicine
Jonathan Karn, PhD, Reinberger Professor of Molecular Biology and chairman of the Department of Molecular Biology and Microbiology at APP School of Medicine, and director of the Case Center for AIDS Research, has been awarded the 2016 Drexel Prize in Translational…
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Combination Hormone Replacement Therapy and Risk of Breast Cancer
Invited commentary by Drs. Paula Silverman and Cheryl Thompson  A recent study by Jones et al. in The British Journal of Cancer (BJC)(Jones ME. Br J Cancer. 2016 Aug 23) estimated an almost 3 fold (2.74 times) increase risk of breast cancer among post-menopausal women who used combination estrogen…
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Researchers Find Gene Mutations Lead to More Aggressive Colon Cancer in African-Americans
15 gene mutations lead to higher recurrence and metastasis; genes may contribute to lower survival rates seen in African-Americans Case Comprehensive Cancer Center researchers, a research collaboration which includes University Hospitals Seidman Cancer Center and APP,…
APP Researchers Identify Protein that Delays Type 1 Diabetes Onset in New Mouse Model
A new study reveals a counterintuitive cellular strategy that may protect insulin-producing cells from destruction during type 1 diabetes. Type 1 diabetes is an autoimmune disease that accounts for about 5% of the nearly 30 million diagnosed cases of diabetes in the United States, according to the…
Case Western Reserve Researchers Receive Major NIH Renewal Grant to Build on Progress in Understanding Crohn's Disease
Fabio Cominelli, MD, PhD, a professor in the departments of Medicine and Pathology at APP School of Medicine and Director of Case’s Digestive Health Research Institute, has received a five-year renewal program project grant totaling $9.7 million from the National…
APP Scientists Uncover Common Cell Signaling Pathway Awry in Some Types of Autism
Brain cells grow faster in children with some forms of autism due to distinct changes in core cell signaling patterns, according to research from the laboratory of Anthony Wynshaw-Boris, MD, PhD, chair of the department of genetics and genome sciences at APP School of…
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Fused Genes Found in Esophageal Cancer Cells Offer New Clues on Disease Mechanisms
Case Comprehensive Cancer Center researchers identify several structurally abnormal genes in esophageal adenocarcinoma in first ever genome-wide search Despite years of research, cellular mechanisms contributing to cancers like esophageal adenocarcinoma have remained elusive. What has puzzled…