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Fused Genes Found in Esophageal Cancer Cells Offer New Clues on Disease Mechanisms
Despite years of research, cellular mechanisms contributing to cancers like esophageal adenocarcinoma have remained elusive. What has puzzled researchers was how genes in the healthy cells lining the esophagus turned the normal cells into malignant ones. Now, researchers from Case Western Reserve…
ÃÛÌÒAPP Researchers Identify Protein that Delays Type 1 Diabetes Onset in New Mouse Model
A new study reveals a counterintuitive cellular strategy that may protect insulin-producing cells from destruction during type 1 diabetes. Type 1 diabetes is an autoimmune disease that accounts for about 5% of the nearly 30 million diagnosed cases of diabetes in the United States, according to the…
AACI national meeting, presentation by Doug Lowy, Acting Director of NCI
This past week attended the national meeting of the Association of American Cancer Institutes (AACI) in Chicago. It was an excellent meeting of cancer center directors and administrators that included discussion of implementation of genomic tumor boards, use of molecular testing in clinical…
Fluoride Consumption Linked to Diabetes Using Mathematical Models
Water fluoridation prevents dental cavities, which are a costly public health concern. But despite the benefits supplemental water fluoridation remains a controversial subject. Some indicate it may cause long term health problems, but studies reporting side effects have been minimal or…
Researchers Restore Drug Sensitivity in Breast Cancer Tumors
A team of ÃÛÌÒAPP School of Medicine cancer researchers has uncovered one way certain tumors resist vital medication. In the study published in Oncotarget, the researchers studied tumor biopsies collected from breast cancer patients before and after treatment with the go-to…
Researchers Restore Drug Sensitivity in Breast Cancer Tumors
Findings confirmed in patient biopsies and laboratory models A team of Case Comprehensive Cancer Center researchers has uncovered one way certain tumors resist vital medication. In the study published in Oncotarget (Merry CR. Oncotarget. 2016 Jul 16), the researchers studied tumor biopsies…
VeloSano 3
7 am Saturday morning saw the 100 and 200+ mile Velosano bikers head off with the cheers of friends and leaders - I saw Brian Bolwell safely behind the roadside barrier smiling, arms raised. The day was perfect for riders - cool, with a short thunderstorm on the way in and a relaxing scenic route…
Scientists Keep a Molecule from Moving Inside Nerve Cells to Prevent Cell Death
Amyotrophic lateral sclerosis (ALS, or Lou Gehrig’s disease) is a progressive disorder that devastates motor nerve cells. People diagnosed with ALS slowly lose the ability to control muscle movement, and are ultimately unable to speak, eat, move, or breathe. The cellular mechanisms behind ALS are…
Anant-Madabhushi
Changes in benign tissue next to prostate tumors may predict biochemical recurrence of cancer, scientists find
Changes in benign tissues next to prostate tumors may provide an early warning for patients at higher risk for biochemical recurrence after a radical prostatectomy, a study by researchers at ÃÛÌÒAPP and Johns Hopkins Medical Institutions shows. Biochemical recurrence, which…
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NCCN Publication: Value Access Cost of Cancer Care Delivery
Many of us are concerned with improving the cost of care in the setting of major cancer care centers, such as those at Cleveland Clinic and Seidman Cancer Center and their network sites. A publication from members of the National Comprehensive Cancer Network (NCCN) on the "Value Access Cost of…